A few questions on axonal growth (nucleogenesis)

  • Thread starter Thread starter visharad
  • Start date Start date
  • Tags Tags
    Growth
Click For Summary
SUMMARY

This discussion focuses on the mechanisms of axonal growth and neurogenesis, specifically examining concentration gradients and molecular functions. It highlights two examples of concentration gradients: the anterior-posterior (AP) and dorsal-ventral (DV) gradients in insects, and the DV gradients in vertebrates that organize the neural tube. Additionally, it discusses the dual roles of molecules like Bone Morphogenetic Protein (BMP) and Epidermal Growth Factor (EGF) across different organisms. The conversation also addresses extrinsic versus intrinsic mechanisms of axonal growth and identifies guidance cues such as semaphorin and netrin that influence axonal navigation.

PREREQUISITES
  • Understanding of neurogenesis and axonal growth mechanisms
  • Familiarity with concentration gradients in developmental biology
  • Knowledge of molecular signaling pathways, specifically BMP and EGF
  • Basic concepts of guidance cues in neural development
NEXT STEPS
  • Research the role of BMP and EGF in different stages of neurogenesis
  • Explore the differences between extrinsic and intrinsic mechanisms of axonal growth
  • Investigate the function of netrin as both an attractant and repellent in axonal guidance
  • Study the various types of guidance cues, including semaphorin and plexin, in neural navigation
USEFUL FOR

Neuroscientists, developmental biologists, and students studying neurogenesis and axonal growth mechanisms will benefit from this discussion.

visharad
Messages
51
Reaction score
0
These are not homework questions. I saw these and some other questions mentioned as discussion in a document. I could find answer to others.

I need just 3 or 4 sentences simple answers to these so that I can get a head-start.

1. Compare at least two different examples where concentration gradients are used during neurogenesis.

Are the following examples OK?
1) AP and DV concentration gradients in insects form body axes, which specify proneural cluster.
2) In vertebrates, regional D-V concentration gradients specify the organization of the neural tube.

2. Compare and contrast at least two different functions for the same molecule in different contexts e.g., different stages of neurogenesis, different organisms, or cellular identity


I was thinking of giving examples of insects (such as drosophila) and vertebrates as organisms. But I do not know which same molecule functions differently in these. Can examples of BMP or EGF molecules be given?

3. Compare and contrast examples of an extrinsic mechanism with an intrinsic mechanism of axonal growth.


4. Give at least three examples of different types of guidance cues that axons use to navigate to their target. How do they work?

I know that attractant and repellent (such as semaphorin/plexin) are different types of guidance cues. But I do not understand in any detail to answer this question.
 
Physics news on Phys.org
For #2, can I give example of netrin molecules because they can act as both attractor as well as repeller of axons?
 
Even if they're not your homework, homework type questions go into the homework section.
 

Similar threads

Replies
1
Views
2K
  • · Replies 12 ·
Replies
12
Views
3K
Replies
8
Views
5K
  • · Replies 1 ·
Replies
1
Views
3K
  • · Replies 2 ·
Replies
2
Views
4K
  • · Replies 18 ·
Replies
18
Views
26K
  • · Replies 15 ·
Replies
15
Views
6K
Replies
3
Views
4K
  • · Replies 39 ·
2
Replies
39
Views
15K