In non-relativistic QM, you assume that energy and momentum are related by non-relativistic equations. In relativistic QM, you assume that energy and momentum are related by relativistic equations.
$$-\frac{\hbar^2}{2m} \nabla^2 \Psi + V \Psi = i \hbar \frac {\partial \Psi}{\partial t}$$
The terms correspond (via the QM operators for momentum and energy) to the non-relativistic
$$\frac{p^2}{2m} + V = E$$
$$K + V = E$$
i.e. kinetic energy plus potential energy equals total energy. ##K = \frac{p^2}{2m}## comes from the familiar ##K = \frac{1}{2}mv^2## for kinetic energy and ##p = mv## for momentum.