Acidity and basicity in amino acids

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SUMMARY

The acidity and basicity of amino acids are primarily determined by their functional groups. In amino acids, the acidic group is identified as the NH3+ (ammonium ion), while the basic group is the COO- (carboxylate ion). This distinction is crucial for understanding their behavior in aqueous solutions, where individual amino acids exist as zwitterions. The concept of conjugate acids and bases is essential for grasping these interactions, as it highlights how proton transfer influences the acid-base properties of amino acids.

PREREQUISITES
  • Understanding of zwitterions in amino acids
  • Familiarity with conjugate acids and bases
  • Knowledge of functional groups in organic chemistry
  • Basic principles of acid-base chemistry
NEXT STEPS
  • Research the role of zwitterions in amino acid behavior
  • Study the concept of conjugate acid-base pairs in detail
  • Explore the impact of side chains on amino acid acidity and basicity
  • Learn about the pKa values of common amino acids
USEFUL FOR

Chemistry students, biochemists, and anyone studying protein structure and function will benefit from this discussion on the acidity and basicity of amino acids.

Rujano
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Hello! I'm having a hard time understanding the acidity and basicity of amino acids.

I read this: the acidic group in an amino acid is NOT the -COOH but the NH3+ and the basic group is COO- and not the NH2... why?

Thanks in advance!
 
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Just revise about "conjugate acids and bases" e.g.

http://chemwiki.ucdavis.edu/Physical_Chemistry/Acids_and_Bases/Conjugate_Acids-base_Pairs#Conjugate_Acid-Base_Pairs

"The conjugate acid of a base is formed when the base gains a proton" etc.
 
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The proper term for 'basicity' is 'alkalinity'.
 
Rujano said:
Hello! I'm having a hard time understanding the acidity and basicity of amino acids.

I read this: the acidic group in an amino acid is NOT the -COOH but the NH3+ and the basic group is COO- and not the NH2... why?

Thanks in advance!

Individual amino acids exist as zwitterions in plain water. Therefore, the acid part will be the group with the protons and the base will be the group capable of accepting a proton. You haven't asked about the side groups yet. That's where it gets interesting.
 

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