Are Moderna/Pfizer/JJ/AZ using the same code for the spike?

  • Thread starter brajesh
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  • #1
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Summary:
Are Moderna/Pfizer/JJ using the same genetic code to make the spike?
Given the variants of the corona virus now appearing, I was wondering,

Are Moderna, Pfizer and Johnson and Johnson and Astrazeneca all using the same genetic code to create the spike protein?
Or more specifically, the spike protein that's made by our body, is it the identical spike protein in all these four vaccines?

I hope this question makes sense?
 

Answers and Replies

  • #3
atyy
Science Advisor
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I'm not sure whether the genetic codes used are exactly the same, but for Pfizer, Moderna, and J&J they should be effectively the same as they are based on a prefusion stabilized, membrane-anchored SARS-CoV-2 full-length spike protein from Jason McLellan's group at UT Austin.

https://news.utexas.edu/2020/02/19/...results-in-new-map-to-support-vaccine-design/
https://science.sciencemag.org/content/367/6483/1260

https://www.nejm.org/doi/full/10.1056/NEJMoa2034577 (Pfizer/BioNTech)
https://www.nejm.org/doi/full/10.1056/nejmoa2022483 (Moderna)
https://www.nationalgeographic.com/...s-solving-puzzle-yielded-coronavirus-vaccines (Pfizer, Moderna, Novavax, Johnson & Johnson)
 
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Likes pinball1970, EPR, brajesh and 1 other person
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Recommendation to Pause Use of Johnson & Johnson’s Janssen COVID-19 Vaccine
Updated Apr. 20, 2021
Print
What you need to know:
The use of Johnson & Johnson’s Janssen (J&J/Janssen) COVID-19 Vaccine is paused for now. This is because the safety systems that make sure vaccines are safe received a small number of reports of people who got this vaccine experiencing a rare and severe type of blood clot with low platelets.
Seek medical care right away if you develop any of the symptoms below.
If you have any questions at all, call your doctor, nurse, or clinic.
[ . . .]
###
https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/JJUpdate.html
 

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