Are we closer to reversing mental retardation?

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Probably not the "near" future. They still need to come up with a compound that would inhibit this PAK enzyme that has no serious side effects, then begin clinical trials which typically take many years.
 
This article isn't about mental retardation in general. It is about fragile X syndrome, a symptom of which is mental retardation. We don't know if all causes of mental retardation work in the same way or not. Thus we can't say one way or another.