Calculate Potassium Clavulanate Mass in 5mL Oral Suspension

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Discussion Overview

The discussion revolves around calculating the mass of potassium clavulanate in a 5mL oral suspension of Augmentin ES, as well as determining the volume of this suspension needed to prepare a specific concentration of amoxicillin trihydrate solution. The scope includes mathematical reasoning and application of chemical principles.

Discussion Character

  • Mathematical reasoning
  • Homework-related

Main Points Raised

  • One participant provides the molar masses and molecular formula for potassium clavulanate and expresses uncertainty about how to use the moles of potassium to find the mass of potassium clavulanate.
  • Another participant emphasizes the need for the molecular formula of potassium clavulanate, suggesting it is essential for the calculations.
  • A different participant raises a question about calculating the volume of suspension required to prepare a 100mL solution of 25ppm amoxicillin trihydrate, providing their calculations and assumptions regarding density.
  • One reply challenges the initial calculation, suggesting that the participant needs to convert ppm to grams per liter before determining the amount of amoxicillin needed.

Areas of Agreement / Disagreement

The discussion contains multiple competing views regarding the calculations and assumptions made, particularly about the conversion of ppm and the necessary steps to find the required mass and volume. No consensus has been reached.

Contextual Notes

Participants have not fully resolved the assumptions regarding the conversion of ppm to grams per liter, nor have they clarified the implications of density on their calculations.

corinnab
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1. Augmentin ES is a powder containing amoxicillin tri hydrate and potassium clavulanate for oral suspension. Each 5mL of reconstituted aqueous oral suspension contains 600mg of amoxicillin trihydrate and 7.07mg of potassium.
Calculate the mass of potassium clavulanate in 5mL of the oral suspension.

What I have found so far
Molar Mass K: 39.1gmol-1
Molar Mass Potassium clavulanate: 237.251gmol-1
Molecular Formula potassium clavulante: C8H8KN05

I think I need to find the moles of K in the 5mL solution and go from there, but I'm not sure how to use the moles of K to solve the problem.
 
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You need the molecular formula for the potassium clavulanate.
 
Also I need to calculate the volume of this suspension required to prepare 100mL of 25ppm(w/v) solution of amoxicillin trihydrate. assume desnity of suspension = 1kgL-1

I'm not sure if what I have done is right:

to get 25ppm I ned 2.5x10-5g/L solute
Conc. of 5mL suspension = 120g/L

Volume required = m/c = 2.5x10-5g/120gL-1 = 2.08x10-8L
 
Seems right except for the first part, you need to multiply the 100 mL=0.010 L by the 25 ppm to get the amount in grams of amoxicillin trihydrate needed however you need to first convert the ppm to g/L assuming this is what they are referring to by "w/v".
 

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