Can microbes combat neurodegeneration? - Apparently YES

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At least for ALS symptoms in mice; and some suspicions in humans based on sequencing the gut microbiome of patients vs. healthy family members in the same household.

They found that the gut bugs produced nicotinamide which "...substantially improved motor abilities and spinal cord gene expression in [the] mice."
https://science.sciencemag.org/content/373/6551/172.long

and other articles at
https://pubmed.ncbi.nlm.nih.gov/34244406/
 
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That's really interesting! It seems like the gut microbiome could have a huge impact on ALS symptoms, not just in mice but potentially in humans as well. I'm looking forward to more research on this topic, and seeing if it can make a difference in the lives of those who suffer from ALS.