Can Pyruvate Supplementation Re-energize the Aging Human Brain?

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Discussion Overview

The discussion centers around the potential effects of pyruvate supplementation on the aging human brain, particularly in light of findings from a study on aging mice. Participants explore the implications of these findings for human trials and the credibility of the research publication.

Discussion Character

  • Debate/contested, Meta-discussion

Main Points Raised

  • Some participants reference a study suggesting that pyruvate supplementation increases energy reserves in the brains of aging mice, potentially enhancing their activity levels.
  • Concerns are raised regarding the credibility of the study's publication, with one participant noting that the publisher is listed as a predatory open-access publisher.
  • Another participant implies that the study may lack validity due to potential issues with peer review, suggesting that it could be misleading for non-experts.
  • There is a proposal to close the discussion thread until the findings are published in a reputable, peer-reviewed journal to avoid spreading misinformation.

Areas of Agreement / Disagreement

Participants express disagreement regarding the validity of the study and its implications for human trials. There is no consensus on whether the findings should be considered credible or actionable at this time.

Contextual Notes

Limitations include concerns about the peer review process and the reputation of the publishing journal, which may affect the interpretation of the study's findings.

wolram
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https://www.sciencedaily.com/releases/2016/03/160316194205.htm
Supplementation with the molecule pyruvate increases the energy reserves in the brain of aging mice, and makes them more energetic and keener to explore their surroundings.

Should this be trialed on humans?
 
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I haven't read the paper associated with the press release, but it's worth noting that the publisher of the article (Frontiers) is on Beall's list of predatory open-access publishers (https://scholarlyoa.com/publishers/).
 
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What @Ygggdrasil is implying: the paper could well be just plain wrong. It probably was not peer reviewed.

And this is hard for non-Science people. And Science people from outside the discipline have problems as well: You read a paper in a journal. It looks okay to you and me. But the chance of us being duped is high because of one fact - the publisher - so we have to say 'Whoa. Maybe not.'

Ugh. (IMO).
 
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I think with this information we should close the thread to prevent someone wandering in with misinformation. Until it is published in an accepted peer reviewed journal we will have to sit on the fence on this.
 
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