In QM this can be used, for instance for the QM harmonic oscillator, to construct eigenfunctions of the Hamiltonian by acting with these creation operators on the vacuum |0>.
In quantum field theory you normally promote the field itself to be an operator in order to treat space and time as labels of these fields; after all, in special relativity they are on equal foot so you shouldn't treat one as an operator (x) and the other as a label (t) parametrizing motion.