To find the derivative of the function 4/sqrt{x}, first rewrite it as 4x^(-1/2). Applying the power rule, the derivative is calculated by multiplying the exponent by the coefficient and decreasing the exponent by one. This results in the derivative being -2x^(-3/2). Therefore, the final expression for the derivative is -2/(2sqrt{x^3}). Understanding these steps is crucial for mastering derivatives involving fractional exponents.