In the measure-theoretic axiomatization of probability, you can regards sets as events, so this question is somewhat well-formed. And yes, there is a difference. You would say events (sets) A and B are independent if P(A n B)=P(A)P(B). If A and B are disjoint, then A n B = emptyset, so P( A n B ) = 0, so A and B are independent iff P(A)=0 or P(B)=0.