Does Linkage Matter in a Cross of Truebreeding Recessives?

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SUMMARY

The discussion confirms that in a cross between true-breeding recessive mutants (AA bb and aa BB), linkage does not affect the outcome, resulting in the double heterozygote genotype (Aa Bb). The participants clarify that regardless of crossover events between the alleles A and b, the gametes produced will yield the same heterozygous result. The analysis emphasizes that whether crossovers occur or not, the degree of linkage does not alter the final genotype of the offspring.

PREREQUISITES
  • Understanding of basic Mendelian genetics
  • Familiarity with genetic terminology such as alleles and gametes
  • Knowledge of crossover events in meiosis
  • Experience with true-breeding and heterozygous genotypes
NEXT STEPS
  • Study the mechanics of genetic linkage and its implications in inheritance patterns
  • Learn about crossover frequency and its effects on gamete formation
  • Explore the principles of Mendelian inheritance in more complex genetic scenarios
  • Investigate the use of genetic mapping techniques to analyze linkage in populations
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Genetics students, researchers in molecular biology, and anyone interested in understanding the principles of inheritance and genetic linkage in breeding experiments.

Yann
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Just a simple question, if I got two genes with 2 recessive mutants, let say the wildtype A and B with mutants a and b. And I cross truebreeding mutants (AA bb, aa BB), linkage, in this situation, doesn't matter, I'll get Aa Bb anyway, am I right ?
 
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Can you clarify your question, I'm not sure what you are asking.
 
I agree, Yan.

Tag the alleles as maternal (M) or paternal (P) chromosome. Then write the tags with the alleles: AM AP bM bP

If no crossover occurs (or an even number of crossovers occur) between A and b, you get a gamete with AM bM and a gamete with AP bP.

If crossover occurs (or an odd number of crossovers occur) between A and B, you get a gamete with AM bP and another with AP bM.

Those are still Ab. The same argument holds for the other double-homozygous parent, so your conclusion is correct, you get the double heterozygote and the degree of linkage won't change that.
 

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