What is linkage strength between gene loci?

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Discussion Overview

The discussion revolves around the concept of linkage strength between gene loci, particularly in the context of a homework question that asks for the amount of crossing over given a linkage strength of 70%. Participants explore the meaning of linkage strength, its representation in percentages, and its relationship to crossing over.

Discussion Character

  • Homework-related
  • Conceptual clarification
  • Debate/contested

Main Points Raised

  • Some participants express confusion about the term "linkage strength," suggesting it is not commonly defined in authoritative sources.
  • There is a proposal that linkage strength may relate to the spatial separation of genes, with closer genes having stronger linkages.
  • Participants question how linkage strength can be quantified as a percentage and what the implications of a 70% linkage strength are.
  • One participant mentions that genetic distances are typically expressed in centimorgans, implying a potential disconnect with the term "linkage strength."
  • Another participant notes that the term "linkage strength" might be used loosely and is not standard terminology, suggesting that "closeness of linkage" is more commonly used.

Areas of Agreement / Disagreement

Participants generally do not agree on the definition and implications of linkage strength, with multiple competing views on its meaning and relevance to crossing over remaining unresolved.

Contextual Notes

There is uncertainty regarding the definition of linkage strength, its representation in percentages, and its relationship to genetic concepts such as crossing over and genetic distance. Participants note a lack of authoritative sources that clarify these terms.

Tyto alba
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Homework Statement


In linkage strength between any two gene loci is 70%,what would be the amount of crossing over between
these loci?

(a) 15% (b)30% (c) 70% (d) none of these.

2. My approach at understanding the concept

I didn't find much about linkage strength from any authentic source.
I can think of two things :
  • The strength of a linkage would be greater if the spatial separation between two genes is less and the lesser if the separation is more. This is semantic. But,
  • how can it be represented in percentage? What does this 100 mean in this 70%? The separation between two genes can be more than 100 map units.
3. Question in details

What does linkage strength mean? How is it related to amount of crossing over?

I would appreciate answers citing some authentic sources.
 
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SanjuktaGhosh said:

Homework Statement


In linkage strength between any two gene loci is 70%,what would be the amount of crossing over between
these loci?

(a) 15% (b)30% (c) 70% (d) none of these.

2. My approach at understanding the concept

I didn't find much about linkage strength from any authentic source.
I can think of two things :
  • The strength of a linkage would be greater if the spatial separation between two genes is less and the lesser if the separation is more. This is semantic. But,
  • how can it be represented in percentage? What does this 100 mean in this 70%? The separation between two genes can be more than 100 map units.
3. Question in details

What does linkage strength mean? How is it related to amount of crossing over?

I would appreciate answers citing some authentic sources.

I suppose an authentic source would be the 600+ page 'Dictionary of Genetics'. It is not mentioned there. I have never heard the term used In a technical defined way; I suppose it can be used in a loose way io speaking. I do not understand how you can be asked such a question and are not supplied with a text that gives you a definition. I think genetic distances are usually expressed in centimorgans.

I would just answer 30% and wait to see if your Prof. gives an explanation.
 
I think it is not a standard term too, if so Google would have shown some results. It was in a question paper, not a homework.

I also thought that way.
But using the word linkage strength to mean amount (proportion) of offspring with parental combination of genes is a bit strange.
 
One usually hears of closeness of linkage rather than strength.
 

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