Thanks Simon, I have had a quick look at the links and will study them in more carefully later. I am not sure though that they get me much closer to understanding the meaning of Heisenberg's uncertainty (HUP) in the context of vacuum fluctuations in QFT. It is interesting that in Zee's QFT in a Nutshell and Lancaster and Blundell's QFT for the Gifted Amateur the references to HUP or quantum fluctuations are either non-existent or relate to virtual particles!
I think what I am struggling with is does the QFT vacuum (ground) state fluctuate (which I am told here it does) and if so is this due to the HUP or some other effect?
If I have understood correctly the Lamb Shift in the hydrogen atom is taken a experimental proof of the vacuum fluctuations.
Clearly I need to study more. Thanks for your input.
Regards Andrew