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Finding mass of acetyl salicylic acid in aspirin tablet

  1. Mar 12, 2015 #1
    1. The problem statement, all variables and given/known data
    25 cm3 of 1M NaOH added to an aspirin tablet. 25cm3 of distilled water also added. Mixture heated for 10 mins. Hydrolysed solution and washings transferred to a 250 cm3 conical flask and made up to the mark (250cm3).
    25 cm3 of the hydrolysed solution is titrated against 0.1M HCl. The average titration is 12.13 cm3 HCl required to reach end point.
    1 mol acetyl salicylic acid reacts with 2 mols NaOH
    1 mol NaOH reacts with 1 mol HCL
    Mr(ASA) = 180.15 g/mol

    theory:
    excess NaOH is added to neutralise the acid in the tablet. the hydrolysed solution is titrated against HCl, the number of moles HCl used proportional to the moles of remaining NaOH.

    2. Relevant equations
    n=C*V/1000

    3. The attempt at a solution
    a) number of moles of NaOH originally added to the aspirin tablet is:
    25*1/1000=0.025 mols

    b) number of moles of NaOH remaining in 250 cm3 hydrolysed solution(not used to hydrolyse ASA):
    =number of moles of HCl used to titrate against 25cm3 hydrolysed solution *10
    =(12.13*0.1/1000)*10 =0.01213 mols

    c) number of moles of NaOH used to hydrolyse the ASA
    = a) - b)
    =0.025-0.01213
    =0.01287 mols

    d) number of moles of acetyl salicylic acid hydrolysed by NaOH:
    =number of moles of NaOH used to hydrolyse ASA/2
    = 0.01287/2 = 0.00644mols

    e) mass of ASA in the tablet:
    =0.00644*180.15
    =1.6g

    however, the mass of ASA should be 300mg (as on the packet)........
    There must be something wrong with my calculation.
    Can someone please kindly check??
     
  2. jcsd
  3. Mar 12, 2015 #2

    Borek

    User Avatar

    Staff: Mentor

    What was the indicator used in the titration?

    It should be 1.16g, not 1.6g, but it doesn't change much. Nothing strikes me as being obviously wrong, and the only thing I have doubts about would change the result to even worse.
     
  4. Mar 12, 2015 #3
    Ah yes it is 1.16g, typo.
    I have discussed with my lab partner and now I know what has gone wrong (4.5 tablets were actually used instead of just 1) which solves my problem.
    But thank you very much for taking the effort to check my working.
     
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