Are there any known gap junction openers/closers for C. elegans? I've googled far and wide for weeks. Trimethylamine, quinine, and carbenoxolone are known to work with connexins in mammals. They also happen to be expensive and require more paperwork, so I don't want to go through the steps just to find they don't work on innexin proteins (inx genes). There are mutant strains (in inx genes) of C. elegans, but gap junctions are important in development too, so I'd think using mutants would meddle with results when trying to assay the function of gap junctions in healthy adults.