Giant neuron around circumference of brain?

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Discussion Overview

The discussion revolves around the discovery of a giant neuron wrapped around the circumference of a mouse's brain and its implications for understanding consciousness. Participants explore whether similar structures could exist in the human brain, the relevance of existing neural connections like the corpus callosum, and the role of the claustrum in consciousness.

Discussion Character

  • Exploratory
  • Debate/contested
  • Conceptual clarification

Main Points Raised

  • Some participants question the significance of the giant neuron discovery in mice and its applicability to humans, noting that humans have the corpus callosum for inter-hemispheric communication.
  • Others suggest that while the existence of similar neurons in humans is possible, it is unlikely to be confirmed soon due to ethical and technical limitations in genetic transformation.
  • There is mention of the claustrum in humans, which is theorized to play a role in conscious thought, but it is clarified that it is not a giant neuron but rather a dense cluster of neurons.
  • Some participants express skepticism about the current understanding of consciousness and the speculative nature of the relationship between neuron structure and consciousness.
  • One participant highlights the need for definitive studies or meta-analyses to support claims about the neuronal structures related to consciousness.
  • There is a suggestion that single-cell stimulation studies in humans could provide insights, though they would be challenging to conduct.

Areas of Agreement / Disagreement

Participants do not reach a consensus on the implications of the giant neuron discovery for human neuroanatomy or consciousness. Multiple competing views and uncertainties remain regarding the relevance of existing neural structures and the speculative nature of consciousness research.

Contextual Notes

Participants note limitations in current understanding, including the speculative nature of claims about consciousness, the need for further research on the claustrum, and the lack of definitive studies supporting the proposed connections between neuron structure and consciousness.

mieral
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We humans already have a "brain coordination system" with a huge number of neural connections - the corpus callosum. It connects the two hemispheres of the human brain. I don't know mouse neuroanatomy well enough to see why the claim you mention is important. Or even if it is valid. Also there is no single giant neuron than encircles normal human brains. AFAIK.

When I follow links in the original popular science article I find mention of the claustrum in humans, which is thought to be a communications center for conscious thought in humans. AFAIK: This hypothesis is still at the maybe level - it needs a lot more research. However the claustrum is not a giant neuron. It is more like a very dense "glob" of many neurons.

People who are current in this field may want to bring us better updates. Here is a blog by a neurologist discussing the claustrum as the 'seat of conscious thought' from 2008. I would think if this were better validated by now, it would have been in popular science magazines by now.
 
Interesting article.

mieral said:
Could this also occur in human brain?
Sure, it is possible that the human brain could contain similar neurons that are still undetected. It is not however likely to be answered soon using these methods since genetic transformation of humans is not some thing that will likely happen soon.
It would be interesting to see what similar techniques would show in primates like monkeys and chimps. They would be a much better indicator of the human situation than mice due to their closer evolutionary relationships.

The relationship of these neurons to consciousness is largely speculative. It is supported by:
The neurons are in the clustrum and have widespread connections in the brain.
The clustrum, when stimulated (affecting large numbers of cells), affects consciousness.
One way of thinking about consciousness attributes widespread connections importance to the process.

Single cell stimulation of these neurons (in humans) would be interesting to do but probably not easy.
Some people (not me) might contend mice (and lots of other animals) don't have consciousness (which leads to apparently unresolvable arguments).
 
jim mcnamara said:
We humans already have a "brain coordination system" with a huge number of neural connections - the corpus callosum. It connects the two hemispheres of the human brain. I don't know mouse neuroanatomy well enough to see why the claim you mention is important. Or even if it is valid. Also there is no single giant neuron than encircles normal human brains. AFAIK.

When I follow links in the original popular science article I find mention of the claustrum in humans, which is thought to be a communications center for conscious thought in humans. AFAIK: This hypothesis is still at the maybe level - it needs a lot more research. However the claustrum is not a giant neuron. It is more like a very dense "glob" of many neurons.

People who are current in this field may want to bring us better updates. Here is a blog by a neurologist discussing the claustrum as the 'seat of conscious thought' from 2008. I would think if this were better validated by now, it would have been in popular science magazines by now.

Mice also have a corpus callosum. But it only coordinates left and right hemisphere, and you don't need both hemisphere to be conscious anyway. If you read the article, it is the interconnectedness between portions of neocortex, a well as claustrom, that makes Koch think it's relevant to consciousness.
 
There could be, but Koch is always speculating about consciousness so I wouldn't hold my breath.
 

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