Hemoglobin Binding: Cooperativity Explained

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Hemoglobin exhibits cooperative binding, meaning that the binding of one oxygen molecule increases the affinity for subsequent oxygen molecules. This phenomenon is crucial for efficient oxygen transport in the bloodstream. Measurements such as the sigmoidal shape of the oxygen dissociation curve provide evidence for this cooperativity. Understanding this concept enhances comprehension of hemoglobin's function and its role in oxygen delivery. Mastering these details can lead to a deeper grasp of respiratory physiology.
jena
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Hi,

Does hemoglobin bind cooperatively or is it oxygen that binds cooperatively?

Thank You:smile:
 
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Let's see if we can help you figure the answer out for yourself so you'll remember it better. What exactly do we mean by cooperative binding when talking about oxygen and hemoglobin? How do we know it happens (i.e., what is measured)?

You should be able to answer the first of my two questions. The second may depend on how you covered it in class. If you don't know the second part, don't worry, we can work through that so you'll know even more than the rest of your class. :smile:
 
Your right I figured it out:redface:

It is cooperatively:smile:
 

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