How Atherosclerosis cause endothelial injury?

  • Thread starter Manish7
  • Start date
  • #1
Manish7
25
0
Atherosclerosis causes accumulation of lipids (cholesterol, cholesterol esters) within the intima of major vessels."Robbins and Cotran, 8 edi." says it is due to endothelial injury rather endothelial dysfunction,which leads to increased permeability, inc. expression of adhesion molecules, altered endothelial function.
but how these risk factors (hyperlipidemia, hypertension, smoking, diabetes mellitus) causes endothelial dysfunction ?
Although Hypertension can damage endothelium, but it must manifest as a case of thrombosis rather than atherosclerosis, leading to MI.
 

Answers and Replies

  • #2
Ryan_m_b
Staff Emeritus
Science Advisor
5,956
720
Is this a homework or coursework question?
 
  • #3
Manish7
25
0
This isn't any homework, I am just asking my query when going through CVS Pathology.
 

Suggested for: How Atherosclerosis cause endothelial injury?

  • Last Post
Replies
6
Views
65K
Medical Knee Injury
  • Last Post
Replies
10
Views
9K
  • Last Post
Replies
9
Views
11K
Replies
5
Views
5K
  • Last Post
Replies
6
Views
3K
  • Last Post
Replies
13
Views
4K
  • Last Post
Replies
3
Views
3K
Replies
3
Views
228
  • Last Post
Replies
7
Views
7K
  • Last Post
Replies
15
Views
25K
Top