How is pyruvate converted to Acetyl-CoA after glycolysis?

[BogMonkey]

After glycolysis where is pyruvate converted to Acetyl-CoA? I know pyruvate can't enter the citric acid cycle but does the pyruvate molecule make its way into the matrix of the mitochondria then get converted to Acetyl-CoA or does it have to be converted before it can even cross the membranes of the mitochondrion?

 

[Sorry!]

After glycolysis where is pyruvate converted to Acetyl-CoA? I know pyruvate can't enter the citric acid cycle but does the pyruvate molecule make its way into the matrix of the mitochondria then get converted to Acetyl-CoA or does it have to be converted before it can even cross the membranes of the mitochondrion?

Pyruvate decarboxylation occurs in the mitochondrial matrix.

 

[BogMonkey]

Thanks.

 

[AyazM]

The way around mitochondrion is glyceraldehyde and malate-oxaloacetate shuttles. You might want to check this out in wikipedia.