HPLC regarding the pore size vs the molecule size

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kl055
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Hi

I have a simple question about HPLC regarding the pore size vs the molecule size of the analyte.

Are there cases when it is desirable to have a pore size smaller than the analyte molecule size?

In this case, the analyte will be eluted first, then the solvent will be eluted later?

Do I misunderstand how HPLC works?
 

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