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HPLC regarding the pore size vs the molecule size

  1. Jun 23, 2014 #1
    Hi

    I have a simple question about HPLC regarding the pore size vs the molecule size of the analyte.

    Are there cases when it is desirable to have a pore size smaller than the analyte molecule size?

    In this case, the analyte will be eluted first, then the solvent will be eluted later?

    Do I misunderstand how HPLC works?
     
  2. jcsd
  3. Jul 3, 2014 #2

    Greg Bernhardt

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    Staff: Admin

    I'm sorry you are not generating any responses at the moment. Is there any additional information you can share with us? Any new findings?
     
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