HPLC regarding the pore size vs the molecule size

[kl055]

Hi

I have a simple question about HPLC regarding the pore size vs the molecule size of the analyte.

Are there cases when it is desirable to have a pore size smaller than the analyte molecule size?

In this case, the analyte will be eluted first, then the solvent will be eluted later?

Do I misunderstand how HPLC works?

 

[Greg Bernhardt]

I'm sorry you are not generating any responses at the moment. Is there any additional information you can share with us? Any new findings?