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Interpretation of double mutants in signaling pathways

  1. Aug 13, 2007 #1
    I found this in my notes, and I memorized it, but I have no idea why this is. Could anyone shed some light:

    Given:
    A mutation in A gives repressed reporter expression, while a mutation in B gives constitutive reporter expression.

    If:
    A double mutation in A and B gives repressed reporter expression... then A positively regulates reporter expression and is negatively regulated by B.

    If:
    A double mutation in A and B gives constitutive reporter expression... then B negatively regulates reporter expression and is negatively regulated by A.

    Why is this the case? Thanks.
     
  2. jcsd
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