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Organic: lanosterol Biosynthetic Cyclization

  1. Oct 14, 2011 #1
    This is a tough one!!

    Shown is the biosynthetic cyclization of oxidosqualene catalyzed by oxidosqualene cyclase (OSC) leading to lanosterol as the final product.

    The reaction starts with a protononation step as shown. Indicate the flow of electrons after the initial protonation step leading to the product given.

    Indicate the flow of electrons by starting your curved arrow at a bond or unshared electron pair.
    In this question, the endpoint of your curved arrow will be an atom.
    You should be able to find appropriate hot spots in the drawing.

    [PLAIN]http://owl.cengage.com/mediaarchives/OrgChemJuly2009/Image/B7.28b.gif [Broken]
     
    Last edited by a moderator: May 5, 2017
  2. jcsd
  3. Oct 14, 2011 #2
     
    Last edited by a moderator: May 5, 2017
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