Radiotracer Decay - What's Left?

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Discussion Overview

The discussion centers on the behavior of a molecule containing a radioactive atom, specifically in the context of positron emission tomography (PET) radiotracers like F-18 FDG. Participants explore what happens to the molecule during radioactive decay, particularly whether the entire molecule is affected or if it remains intact after the decay event.

Discussion Character

  • Exploratory
  • Technical explanation
  • Debate/contested

Main Points Raised

  • One participant questions whether the decay of a radiotracer like F-18 FDG results in the molecule being blown apart or if it remains intact as O-18.
  • Another participant suggests that the electron configuration of the daughter product influences the outcome of the decay process.
  • A different viewpoint indicates that the daughter product typically dissociates from the tagged molecule, which remains intact.
  • One participant argues that the recoil of the nucleus during decay is negligible compared to the energy of the emitted positron-neutrino pair, implying that imaging can still occur effectively.

Areas of Agreement / Disagreement

Participants express differing views on whether the decay affects the integrity of the entire molecule, with no consensus reached on the exact nature of the decay's impact.

Contextual Notes

The discussion involves assumptions about the types of decay and the specific behavior of molecules in radiochemistry, which may not be fully resolved or defined.

Chyral
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Greetings all. I'm a just a chemist banging my head about some what seems to me as fundamentally a nuclear physics question, so please bear with me.

If you have a molecule bearing a radioactive atom, a PET radiotracer, say F-18 FDG or some such beast, and it decays (to O-18 correct?) what exactly happens to the entire molecule? Another way of putting it is: As the positron-neutrino pair is released, is the rest of the tracer molecule blown apart by kinetic energy from the decay event?
Or am I thinking too much in a classical sense and you are left with a molecule happily bearing O-18 rather than F-18?
And lastly, does the answer depend on what type of decay is occurring?
 
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It depends on the electron configuration of the radioactive elements daugher.

You can look on wikipedia for example, on all decay modes. Then there are things like "Internal conversion", "electron capture"; which changes the electron configuration of the daugher atom.
 
Thanks for the reply! So it looks like this was the wrong place to post (sorry about that). I have asked people here in radiochemistry and medical physics and I still am left without an answer, though. Oh well.
 
I'm not a radiochemist, but I believe that most of the time the daughter product dissociates from the tagged molecule/pharmaceutical (which remains intact)
 
Chyral said:
If you have a molecule bearing a radioactive atom, a PET radiotracer, say F-18 FDG or some such beast, and it decays (to O-18 correct?) what exactly happens to the entire molecule? Another way of putting it is: As the positron-neutrino pair is released, is the rest of the tracer molecule blown apart by kinetic energy from the decay event?
Or am I thinking too much in a classical sense and you are left with a molecule happily bearing O-18 rather than F-18?
And lastly, does the answer depend on what type of decay is occurring?

Hello Chyral,

I would say that the recoiling of the nucleus is negligible (specially for F) wrt the energy of positron-neutrino pair. In some way, that's why you can do imaging.
 

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