Suzuki Cross-Coupling work-up question

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SUMMARY

The discussion centers on the Suzuki Cross-Coupling reaction utilizing "Nickel-Catalyzed Suzuki-Miyaura Couplings in Green Solvents" by Ramgren et al. The reaction employs NiCl2(PCy3)2 and tripotassium phosphate in t-amyl alcohol to couple bromo-aryl with boronic acid. During the work-up, the product is transferred into a test tube containing 1M HCl, raising questions about the solubility of biphenyl products in the aqueous layer. Clarification is sought regarding the solubility of organic molecules in 1M HCl.

PREREQUISITES
  • Understanding of Suzuki Cross-Coupling reactions
  • Familiarity with nickel catalysts, specifically NiCl2(PCy3)2
  • Knowledge of organic solvent properties, particularly t-amyl alcohol
  • Basic principles of solubility in acidic environments
NEXT STEPS
  • Research the solubility of biphenyl and similar organic compounds in acidic solutions
  • Study the mechanisms of Suzuki Cross-Coupling reactions
  • Explore alternative solvents for Suzuki reactions and their impact on product solubility
  • Investigate the role of tripotassium phosphate in facilitating the reaction
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Chemistry students, organic chemists, and researchers involved in synthetic organic chemistry, particularly those focusing on coupling reactions and solvent effects.

worryingchem
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Hi, in class I'm doing a Suzuki Cross Coupling reaction based on
"Nickel-Catalyzed SuzukiMiyaura
Couplings in Green Solvents" by Stephen D. Ramgren, Liana Hie, Yuxuan Ye, and Neil K. Garg.
The reaction involved the bromo-aryl reacting with the boronic acid in heated t-amyl alcohol in the presence of NiCl2(PCy3)2 and tripotassium phosphate.

During the work-up, the first thing we did was transferred our solvent into a test tube of 1M HCl. The product is supposed to be in the aqueous layer, but I don't know how a biphenyl product would dissolve in the aqueous layer.
Can someone clear this up for me? Thank you.
suzuki rx.JPG
 
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Can you think of any organic molecules that are soluble in 1M HCl?
What are R1 and R2?