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Suzuki Cross-Coupling work-up question

  1. Mar 19, 2015 #1
    Hi, in class I'm doing a Suzuki Cross Coupling reaction based on
    "Nickel-Catalyzed SuzukiMiyaura
    Couplings in Green Solvents" by Stephen D. Ramgren, Liana Hie, Yuxuan Ye, and Neil K. Garg.
    The reaction involved the bromo-aryl reacting with the boronic acid in heated t-amyl alcohol in the presence of NiCl2(PCy3)2 and tripotassium phosphate.

    During the work-up, the first thing we did was transferred our solvent into a test tube of 1M HCl. The product is supposed to be in the aqueous layer, but I don't know how a biphenyl product would dissolve in the aqueous layer.
    Can someone clear this up for me? Thank you.
    suzuki rx.JPG
  2. jcsd
  3. Mar 21, 2015 #2
    Can you think of any organic molecules that are soluble in 1M HCl?
    What are R1 and R2?
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