Teixobactin: A Promising New Antibiotic from Uncultured Bacteria

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In summary, the paper showed that a new antibiotic that doesn't exhibit detectable resistance can be developed and has good potential against gram-negative bacteria.
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Ryan_m_b
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This paper was shown to me today by a colleague:

A new antibiotic kills bacteria without detectable resistance
L, Ling et al (2015) Nature
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14098.html
Abstract said:
Antibiotic resistance is spreading faster than the introduction of new compounds into clinical practice, causing a public health crisis. Most antibiotics were produced by screening soil microorganisms, but this limited resource of cultivable bacteria was overmined by the 1960s. Synthetic approaches to produce antibiotics have been unable to replace this platform. Uncultured bacteria make up approximately 99% of all species in external environments, and are an untapped source of new antibiotics. We developed several methods to grow uncultured organisms by cultivation in situ or by using specific growth factors. Here we report a new antibiotic that we term teixobactin, discovered in a screen of uncultured bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II (precursor of peptidoglycan) and lipid III (precursor of cell wall teichoic acid). We did not obtain any mutants of Staphylococcus aureus or Mycobacterium tuberculosis resistant to teixobactin. The properties of this compound suggest a path towards developing antibiotics that are likely to avoid development of resistance.

It's a fascinating paper, not just for the good results that teixobactin seems to have against gram-negative bacteria but also for it's use of the Ichip (reported in this paper from 2010). The Ichip is a system for cultivating so-called uncultivable bacteria. It works by isolating individual bacteria into small cells on a slide, a semi-permeable membrane covers the cells (trapping the bacteria) and the whole thing is placed in soil. The bacteria survive in this environment and can be easily studied. It's reported that the Ichip can culture 50% of the bacterial species placed into it, a huge improvement over the 1% standard methods generate.

It will be interesting to see if teixobactin comes to anything and if how widespread this method becomes in the pursuit of new antibiotics.
 
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Wow, that's great news, and very promising! Thanks Ryan. :-)
 

Related to Teixobactin: A Promising New Antibiotic from Uncultured Bacteria

1. What is Teixobactin?

Teixobactin is a newly discovered antibiotic that was isolated from soil bacteria in 2015. It has shown promising results in fighting against drug-resistant bacteria, including MRSA and tuberculosis.

2. How does Teixobactin work?

Teixobactin works by binding to and disrupting the cell walls of bacteria. This prevents the bacteria from growing and reproducing, ultimately leading to their death.

3. Is Teixobactin safe for human use?

Early studies have shown that Teixobactin is non-toxic to human cells, making it a potentially safe option for treating bacterial infections. However, further research and clinical trials are needed to confirm its safety and effectiveness.

4. What makes Teixobactin different from other antibiotics?

Teixobactin is unique in that it has a new mechanism of action and targets bacteria in a different way compared to other antibiotics. This makes it a promising option for treating drug-resistant bacterial infections.

5. When will Teixobactin be available for use?

Teixobactin is still in the early stages of development and is not yet available for use. It will likely take several years of further research and clinical trials before it can be approved and made widely available for use in treating bacterial infections.

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