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I want to do some sampling of the possible outcomes. I guess random sampling (Monte-Carlo technique) is the way forward, but my question is, theoretically, when selecting random numbers for the inputs, should I discard combinations that have already been used?

For large samples it probably won't in practice make any difference, but say I had I have 3 variables a, b and c, each of which can be (0,1,2,3,4,5,6,7,8,9), and I want to compute 100 outputs. Say I've already used {a = 1, b = 8, c = 4}, in theory should I check whether I've used this combination already?

Intuitively it seems like I'll get a more accurate result if I discard already-used inputs, but then the inputs won't be random.