What are the future risks and treatments for prion diseases like vCJD?

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  • Thread starter Thread starter hammertime
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Discussion Overview

The discussion centers on the future risks and potential treatments for prion diseases, specifically variant Creutzfeldt-Jakob disease (vCJD). Participants explore the likelihood of an epidemic, the current state of research, and possible therapeutic approaches.

Discussion Character

  • Exploratory
  • Debate/contested
  • Technical explanation

Main Points Raised

  • One participant questions the potential for prion diseases like vCJD to become an epidemic, suggesting a range of possible fatalities.
  • Another participant argues that prion diseases are not very transmissible and have a low incidence, making an epidemic unlikely.
  • A third participant references a report from the International Society for Infectious Diseases indicating a steady decline in human prion diseases.
  • One participant describes the mechanism of prion diseases, emphasizing the role of protein replication and the conversion of normal proteins into defective ones.
  • A participant seeks clarification on the mention of ozone as a potential treatment for prion diseases.

Areas of Agreement / Disagreement

Participants express differing views on the likelihood of prion diseases becoming an epidemic, with some suggesting it is unlikely while others raise concerns about potential risks. The discussion on treatment options, including ozone, remains unresolved.

Contextual Notes

There are limitations in the discussion regarding the assumptions about transmissibility and the definitions of epidemic risk. The mention of ozone as a treatment lacks detailed exploration and remains speculative.

hammertime
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What are the odds of prion diseases, such as vCJD (which can be contracted by eating contaminated beef and can have an incubation period of decades), becoming an epidemic in the future? Could we be looking at hundreds, thousands, or even millions of lives lost?

What all research is being done in the area of prion diseases? Are we any closer to a treatment or therapy? I've heard of the possibility of using ozone.
 
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hammertime said:
becoming an epidemic in the future? Could we be looking at hundreds, thousands, or even millions of lives lost?
Not very transmissible and very low incidence - so unlikely.
 
The International Society for Infectious Diseases has monitored a steady decline in human prion diseases of all kinds.

Archive Number 20100107.0076
Published Date 07-JAN-2010
Subject PRO/AH/EDR> Prion disease update 2010

http://www.promedmail.org
 
prion disease is very interesting in that it is the "replication" of protein. In other words, the 3-D geometry of the defective protein is the disease causing agent, and this defective protein will encounter a normal healthy version of the protein, interact with the normal healthy version of the protein, and then convert it to the abnormal defective version of the protein, and the process just repeats itself like a chain reaction.

these diseases are quite rare.
 
Can anyone elaborate on what the topic starter said about the "ozone" as treatment?
 

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