Most nuclear reactions, fission and fusion, result in some loss of mass that is converted into energy. A positron (positively charged particle same size as electron) and electron collison results in all the matter being converted into energy.
Chemical reactions that generate energy do so because the end up with less internal energy afterwards than before the chemicla reaction. Most of the energy is related to the kinetic energy of the electrons "orbiting" around the atoms in a molecule. When the electrons drop down to a lower energy state, energy is released.
Lasers do a similar thing, except they convert energy into a light. Energy is used to increse the energy state of the electons of a gas or crystal. Then a passing photon triggers the electron to drop it's energy state and produce a photon in the same direction (and phase?) as the original photon. The mirrors in a laser is what controls the ultimate direction. Initially, photons are going off in all directions, but if not lined up with the mirrors they just get absorbed by the walls of the cylinder. Eventually (a very short time, the ones lined up with the mirrors keep being reflected back and forth, generating more photons in the same direction (and phase). One of the mirrors is a partial mirror, and this is where the beam eminates from.