What Is the Correct Sequence of Protein Processing in Cells?

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SUMMARY

The correct sequence of protein processing in cells involves six distinct events. First, a membrane protein is synthesized in the rough endoplasmic reticulum. Next, the unmodified protein is present in the membrane of a vesicle, followed by the addition of sugars to form a glycoprotein. The glycoprotein then resides in the membrane of a vesicle, where the sugars are subsequently modified. Finally, the protein is positioned in the plasma membrane with the sugar modification facing outside the cell. This sequence is essential for proper protein function and cellular communication.

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  • Understanding of rough endoplasmic reticulum function
  • Knowledge of glycoprotein structure and formation
  • Familiarity with vesicular transport mechanisms
  • Basic concepts of plasma membrane composition
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  • Study the process of protein synthesis in the rough endoplasmic reticulum
  • Research glycosylation and its impact on protein function
  • Explore vesicle trafficking and membrane fusion mechanisms
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Cell biologists, biochemists, and students studying molecular biology who are interested in the mechanisms of protein processing and cellular functions.

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Homework Statement



Consider the following events:

1) The protein has sugar added to become a glycoprotein.

2) The protein is in the plasma membrane with the sugar modification facing outside the cell.

3) A membrane protein is synthesized in the rough endoplasmic reticulum.

4) The glycoprotein is present in the membrane of a vesicle.

5) The sugars on the glycoprotein are modified.

6) The unmodified protein is present in the membrane of a vesicle.

What is the correct order of the events?



Homework Equations



none

The Attempt at a Solution



3) A membrane protein is synthesized in the rough endoplasmic reticulum.
6) The unmodified protein is present in the membrane of a vesicle.
1) The protein has sugar added to become a glycoprotein.
4) The glycoprotein is present in the membrane of a vesicle.
5) The sugars on the glycoprotein are modified.
2) The protein is in the plasma membrane with the sugar modification facing outside the cell.
 
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I agree. But then again it doesn't appear to offer much choice anyway.
 

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