The usual interpretation seen often in an introductory quantum field theory course is the calculations of particle scattering or decay using the LSZ formula I mentioned above. This formula relates an ("amputated") N-point function to a scattering/decay process involving N particles coming both "in" and "out." For example, let's say you have a theory of scalar particles, call them mesons. If you want the scattering amplitude of two mesons coming in and two mesons coming out, it is related to the 4-point function.
But once again, since all operators in your theory can be written in terms of the fields, and expectation values of operators are then N-point functions, they show up everywhere.