What regulates the ageing process?

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In summary, the life span is largely determined by genetics, but there are environmental and metabolic constraints that also play a role.
  • #1
AlexmBIOSS
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Hello,
I had a discussion last night that I was not sure how to develop fully. There are some species of Turltes which live for 255 years and some that live substantially less, The sturgeon fish http://en.wikipedia.org/wiki/Sturgeon" live extremely long outlasting tons of other fish, some species of trees can be only slightly different from relatives but live an order of magnitude longer.
So my question is: Is it a combination of environment and genetics that changes the life span through the ageing process? (you cannot change the environment without altering the ageing process so factors like food etc come largely into play in a very sensitive condition set) Or is it almost purely genetic? And I can't find literature for the gene list and difference. I would love to find out which genes are different between species that age differently.

The wikipedia article http://en.wikipedia.org/wiki/Senescence" has some references to genes but it is general and not specific to the organism relatives which is more interesting.

Best wishes to all,
Alex
 
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  • #3
I'm not sure but it also has to do with the required energy the organism needs to live its life and how fast the organism grows. The cells of a turtle do not divide very fast and turtles require relatively little energy to continue to live. They can for extended periods of time even with food or water.

Cell division in humans occurs much faster and we require greater amounts of energy to live.
 
  • #4
Like the other posters point out, there are a LOT of factors that go into determining how an organism ages; or better yet, if the organism ages well.

One aspect of our genetics that is of great importance to the aging process are our telomeres - repeating pieces of "junk" DNA at the end of our chromosomes that serve to protect DNA from replicative damage.

When your DNA replicates, the process results in an uneven "clipping" of the ends of the DNA that actually shortens the length of the strand. The telomeres help ensure that "essential" DNA isn't getting clipped - in fact, cells will stop replicating entirely before they reach a point that would damage DNA. Telomeres can be thought of essentially as buffers that guard your DNA.

So, if you have short telomeres, cell replication stops after fewer divisions. If you have long telomeres, it takes longer for the same thing to occur.

Of course, as with everything in biology, it isn't this simple.

There is an enzyme called Telomerase that repairs telomeres. You can have short telomeres and effective telomerase and protect your DNA for a lot longer than someone with long telomeres and ineffective telomerase.

This is but one process that contributes to aging but it's a very key component to the process and a lot of scientists are trying to figure out how feasible it is to use telomerase to extend lives.
 
  • #5
Note however that there is a very fine line for the telomeres, for if a cell abuses the telomerase, it becomes a cancer cell.
 
  • #6
Clearly the death executioner gene ( http://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Dm&CID=1719 ) is responsible for all deaths.

On a more serious note, you should read http://en.wikipedia.org/wiki/Metabolic_theory_of_ecology

a small portion of it:
"Small animals tend to grow fast, breed early, and die young. According to MTE, these patterns in life history traits are constrained by metabolism. An organisms’ metabolic rate determines its rate of food consumption, which in turn determines its rate of growth. This increased growth rate produces trade-offs that accelerate senescence. For example, metabolic processes produce free radicals as a by-product of energy production. These in turn cause damage at the cellular level, which promotes senescence and ultimately death. Selection favors organisms which best propagate given these constraints, so as a result smaller, shorter lived organisms tend to reproduce earlier in their life histories."
 
  • #7
There is a built-in lifespan for humans, which is ~85. The book The Rectangular Curve discusses this.
 

Related to What regulates the ageing process?

What regulates the ageing process?

1. What is the main cause of ageing?
The ageing process is regulated by a combination of genetic, environmental, and lifestyle factors. While some scientists believe that genetic factors play a significant role, others argue that environmental and lifestyle factors, such as diet and exercise, have a larger impact on ageing.

2. Can ageing be reversed?
At this point, there is no scientific evidence that ageing can be reversed. However, scientists continue to research potential ways to slow down the ageing process and improve overall health and longevity.

3. How does metabolism impact ageing?
Metabolism is the process by which our bodies convert food into energy. Many scientists believe that a slower metabolism is associated with a longer lifespan, as it reduces the production of harmful byproducts that can contribute to ageing.

4. Are there any lifestyle factors that can slow down ageing?
Yes, maintaining a healthy lifestyle can have a significant impact on the ageing process. Regular exercise, a balanced diet, and reducing stress levels can all help slow down the ageing process and improve overall health and longevity.

5. What role do telomeres play in ageing?
Telomeres are the protective caps on the ends of our chromosomes, and they play a crucial role in the ageing process. As we age, our telomeres naturally shorten, which can lead to cell damage and contribute to the ageing process. Scientists are currently researching ways to prevent or reverse telomere shortening to slow down ageing.

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