Why is magnesium an NMDA antagonist?

  1. The NMDA receptor is a ligand gated non selective cation channel. It allows Na+ and to a lesser extent Ca2+ and K+ to pass through. I read that Mg2+ clogs up the pore. Why would Mg2+ block the channel but not Ca2+? Ca2+ is larger so I'd expect that to be more likely to block an ion channel. Is it because Mg2+ is more electronegative than Ca2+?
  2. jcsd
  3. I'd say its because Mg2+ is the smallest charge 2 ion and is more reactive than Ca2+; clogging up the pore might just mean that it deactivates the protein, not actually block the pore, right? Just my opinion, I'm no expert.
  4. Heres a quote from an abstract:

    In a voltage dependent manner so what you said must be correct. Magnesiums size-charge ratio is behind it. I read something about NMDA receptors being partially voltage gated.
Know someone interested in this topic? Share this thead via email, Google+, Twitter, or Facebook

Have something to add?