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Why PPAR-gamma is called peroxisome proliferator activator receptor? What connection does it have with peroxisome per se? Does it proliferate the number of peroxisomes inside a cell?
https://en.wikipedia.org/wiki/Peroxisome_proliferator-activated_receptorPPARs were originally identified in Xenopus frogs as receptors that induce the proliferation of peroxisomes in cells.[7] The first PPAR (PPARα) was discovered during the search of a molecular target for a group of agents then referred to as peroxisome proliferators, as they increased peroxisomal numbers in rodent liver tissue, apart from improving insulin sensitivity.[8] These agents, pharmacologically related to the fibrates were discovered in the early 1980s. When it turned out that PPARs played a much more versatile role in biology, the agents were in turn termed PPAR ligands. The best-known PPAR ligands are the thiazolidinediones; see below for more details.