Molecular Weight for nucleotides

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Discussion Overview

The discussion revolves around the concept of molecular weight for nucleotides, specifically addressing the meaning of "daltons" and the notation "(g/M)". Participants explore the definitions and calculations related to molecular weight, as well as the significance of using carbon-12 as a reference point.

Discussion Character

  • Technical explanation
  • Conceptual clarification
  • Debate/contested

Main Points Raised

  • Some participants explain that a dalton is an atomic mass, with carbon-12 having a mass of 12.0000 Da, and that molecular weight refers to the mass of one mole of a molecule.
  • There is a question about the meaning of "M" in the notation g/M, with some suggesting it stands for "mole".
  • One participant asserts that a dalton is equivalent to the number of grams that correspond to a mole, leading to the conclusion that gram/mol equals Da.
  • Another participant challenges the exactness of the mass of carbon-12, suggesting that it is not precisely 12 grams, and provides a breakdown of the mass contributions from protons, neutrons, and electrons.
  • There is a mention of the historical context of using carbon as a reference for atomic mass due to its ease of purification.

Areas of Agreement / Disagreement

Participants express differing views on the exactness of atomic masses and the interpretation of the notation g/M. No consensus is reached regarding the precise definitions and implications of these terms.

Contextual Notes

Some statements involve assumptions about the definitions of atomic mass and molecular weight, and there are unresolved questions about the notation used in the context of molecular weight calculations.

mountain
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When it says; "Molecular Weight: daltons (g/M)" What does daltons mean and what does (g/M) stand for? Does g/M stand for g/mol or what?

How can they calculate Molecular Weight for nucleotides?


Thanks for any inputs.
 
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A dalton is an atomic mass. For instance C12 has a mass of 12.0000 Da. The mw is the mass of 1 mole of a particular molecule. By definition 1 mole of carbon atoms weighs 12 grams.
 
Thanks.

But what does M stand for in g/M?
 
mountain said:
Thanks.

But what does M stand for in g/M?

You had it right...mole.
 
Monique said:
A dalton is an atomic mass. For instance C12 has a mass of 12.0000 Da. The mw is the mass of 1 mole of a particular molecule. By definition 1 mole of carbon atoms weighs 12 grams.
(why only four zeros?)

(1) C12 has a mass of 12 Da (by definition; exactly 12, there is no uncertainty)
(2) a mol of C12 atoms weighs 12 grams (by definition)

From (1) and (2) it follows that a dalton is the number of grams that go into a mol (gram/mol)
__________________________________________________
(1) C12 = 12 Da <--> mol C12 = mol 12 Da
(2) mol C12 = 12 gram
(substitute 2 into 1) 12 gram = mol 12 Da <--> gram/mol = Da
 
doesn't g/M mean g/mol/L?
 
its not exactly 12, and its not exactly 16 for oxygen either

but they decided to make it 12 anywho. so just use 12 as a whole number

6 protons = 6 x 1.007277 6.043662
6 neutrons = 6 x 1.008665 6.051990
6 electrons = 6 x 0.000548 0.003288
Total 12.098940
 
Last edited:
Carbon was easy to purify, that is why they used it as a reference and why it is the whole number 12.
 

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