how does Helicase unwind the dna strands?what is the chemical Process


by ARAVIND113122
Tags: chemical, helicase, process, strandswhat, unwind
ARAVIND113122
ARAVIND113122 is offline
#1
Jul18-11, 10:16 AM
P: 54
how does Helicase unwind the dna strands?what is the chemical Process involved?what is the chemical reaction?
Phys.Org News Partner Biology news on Phys.org
Chickens to chili peppers: Scientists search for the first genetic engineers
The malaria pathogen's cellular skeleton under a super-microscope
Deadly human pathogen Cryptococcus fully sequenced
Ygggdrasil
Ygggdrasil is offline
#2
Jul18-11, 12:04 PM
Other Sci
Sci Advisor
P: 1,342
Helicases use the free energy from ATP hydrolysis (ATP + H2O --> ADP + PO4) in order to move directionally along DNA (double stranded and/or single stranded) as well as peel apart the two strands of DNA. How these enzymes couple this chemical reaction to movement of the helicase and strand separation is not completely understood and is an active area of research.

Here's a few recent review papers I talking more about how helicases work and ongoing experimental work trying to tease out their mechanism:

http://www.nature.com/nrm/journal/v9...l/nrm2394.html
http://journals.cambridge.org/action...ne&aid=7881876
http://www.sciencedirect.com/science...59440X11000042
That Neuron
That Neuron is offline
#3
Jul21-11, 02:23 PM
P: 76
http://en.wikipedia.org/wiki/Helicase

Helicases as said above use ATP to move along the DNA strand, along the way they break hydrogen bonds I think by creating an area of negative electrostatic charge around them...At least that is what my mind is saying, but I may be mistaken


Register to reply

Related Discussions
[b]1. The problem statement, all variables and given/known Biology, Chemistry & Other Homework 2
DNA Transcription: Where do genes begin and end? Biology 5
genetics: transcription translation help! Biology 2
Gene Transcription/DNA Replication Biology 1
Gene Transcription vs DNA replication Introductory Physics Homework 0