|Jul18-11, 10:16 AM||#1|
how does Helicase unwind the dna strands?what is the chemical Process
how does Helicase unwind the dna strands?what is the chemical Process involved?what is the chemical reaction?
|Jul18-11, 12:04 PM||#2|
Helicases use the free energy from ATP hydrolysis (ATP + H2O --> ADP + PO4) in order to move directionally along DNA (double stranded and/or single stranded) as well as peel apart the two strands of DNA. How these enzymes couple this chemical reaction to movement of the helicase and strand separation is not completely understood and is an active area of research.
Here's a few recent review papers I talking more about how helicases work and ongoing experimental work trying to tease out their mechanism:
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