The newly identified antibiotic, zosurabalpin, effectively targets carbapenem-resistant Acinetobacter baumannii (CRAB), a critical pathogen responsible for high mortality rates in hospitalized patients. CRAB is recognized as a top-priority threat by the World Health Organization and the U.S. Centers for Disease Control and Prevention, causing significant health issues in the U.S. annually. Zosurabalpin disrupts the transport of a key toxin within the bacterial cell, presenting a novel mechanism of action against this superbug. However, the potential for resistance to develop with widespread use remains a significant concern.
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. . . carbapenem-resistant Acinetobacter baumannii, or CRAB, is a nightmare for hospitals worldwide, as it kills roughly half of all patients who acquire it.
Identified as a top-priority pathogen by both the World Health Organization and the U.S. Centers for Disease Control and Prevention, CRAB is the most common form of a group of bacteria that are resistant to nearly all available antibiotics. Victims are typically hospitalized patients who are already sick with blood infections or pneumonia. In the U.S. alone, the bug sickens thousands and kills hundreds every year.
researchers have identified a new antibiotic that appears to effectively kill A. baumannii.
The compound, zosurabalpin, attacks bacteria from a novel angle, disrupting the route that a key toxin takes on its journey from inside the bacterial cell to the outer membrane that shields the bug from the immune system’s defensive onslaughts.