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- Should doctors prescribe Acetylcysteine to anyone (not only COVID patients) who is taking high doses (not overdose) of acetaminophen/paracetamol for a long period of time?
Acetylcysteine (or N-Acetylcysteine) is an important drug that is used to loosen thickened mucus in the lungs. In addition to that, it is also used for treating paracetamol/acetaminophen poisoning.
Many people who have contracted SARS-CoV-2 are suffering from very high fever for a long period of time. Doctors are prescribing high doses of acetaminophen (or paracetamol) as antipyretic for suppressing the fever. For example, take the case of my father. His fever started on 31st August; on 3rd September he tested positive for COVID-19 (in the RT-PCR test), and we had to admit him to the hospital on 8th September for persistent high fever. Since day one of the fever, he has been taking paracetamol, at first 4g a day (with a gap of 6 hours between two successive doses of 1g each) for three days, and thereafter 3g a day (gap of 8 hours between two successive doses). Currently, in the hospital, he is being given intravenous paracetamol at the same dose (3g a day). (Note that none of this was/is self-medication; the doctor has prescribed these doses). If a dose is missed, the fever is returning, the temperature reaching as high as 103°F.
While acetaminophen is required for suppressing the fever, high doses (not overdose) of this drug have ill-effects on kidney and liver. My father is not the only person who is taking such high doses of this drug. Our doctor agrees that there are side effects, but he is not bothered to do anything about the side-effects.
My question: should doctors prescribe Acetylcysteine to anyone (not only COVID patients) who is taking high doses of paracetamol for a long period of time? Is there any study which says this should be done? Any paper against this thought?
Edit (last paragraph): made my question a bit clearer.
Many people who have contracted SARS-CoV-2 are suffering from very high fever for a long period of time. Doctors are prescribing high doses of acetaminophen (or paracetamol) as antipyretic for suppressing the fever. For example, take the case of my father. His fever started on 31st August; on 3rd September he tested positive for COVID-19 (in the RT-PCR test), and we had to admit him to the hospital on 8th September for persistent high fever. Since day one of the fever, he has been taking paracetamol, at first 4g a day (with a gap of 6 hours between two successive doses of 1g each) for three days, and thereafter 3g a day (gap of 8 hours between two successive doses). Currently, in the hospital, he is being given intravenous paracetamol at the same dose (3g a day). (Note that none of this was/is self-medication; the doctor has prescribed these doses). If a dose is missed, the fever is returning, the temperature reaching as high as 103°F.
While acetaminophen is required for suppressing the fever, high doses (not overdose) of this drug have ill-effects on kidney and liver. My father is not the only person who is taking such high doses of this drug. Our doctor agrees that there are side effects, but he is not bothered to do anything about the side-effects.
My question: should doctors prescribe Acetylcysteine to anyone (not only COVID patients) who is taking high doses of paracetamol for a long period of time? Is there any study which says this should be done? Any paper against this thought?
Edit (last paragraph): made my question a bit clearer.
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