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Medical Allosteric effect on hemeglobin

  1. Sep 30, 2011 #1
    where do hydrogen ion(Bohr effect) and 2,3 BPG bind to? porphyrin or just the globin chains?
  2. jcsd
  3. Sep 30, 2011 #2


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    The protein chains. BPG binds to deoxy-Hb so favours deoxygenation. A bit unusual in that it binds just one molecule BPG per Hb tetramer (in the cavity between the beta chains).

    I believe the Bohr protons bind in lots of places but I am not up to date.

    This site is not for getting basic textbook information, more for conceptual difficulties and puzzles when you read the books or try to answer the problems. There is lots on the web e.g. http://www.biochem.arizona.edu/classes/bioc460/spring/460web/lectures/LEC8-9_MbHb_08-ppt.pdf

    and lots of others.
    Last edited by a moderator: Apr 26, 2017
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