Allosteric effect on hemeglobin

  • Context: Medical 
  • Thread starter Thread starter weng cheong
  • Start date Start date
Click For Summary
SUMMARY

The discussion focuses on the binding sites of hydrogen ions (Bohr effect) and 2,3-bisphosphoglycerate (2,3 BPG) in hemoglobin (Hb). It is established that 2,3 BPG binds specifically to deoxyhemoglobin, favoring deoxygenation, and occupies a unique cavity between the beta chains of the Hb tetramer. The Bohr protons are noted to bind in multiple locations, although specific binding sites were not detailed in the discussion. The conversation emphasizes the need for deeper understanding rather than basic textbook information.

PREREQUISITES
  • Understanding of hemoglobin structure and function
  • Knowledge of the Bohr effect in physiology
  • Familiarity with 2,3-bisphosphoglycerate (2,3 BPG) role in oxygen transport
  • Basic concepts of protein binding interactions
NEXT STEPS
  • Research the structural biology of hemoglobin and its tetrameric form
  • Study the mechanisms of the Bohr effect in detail
  • Explore the role of 2,3 BPG in various physiological conditions
  • Investigate the implications of hemoglobin binding dynamics on oxygen delivery
USEFUL FOR

Biochemists, molecular biologists, and students studying respiratory physiology who seek to deepen their understanding of hemoglobin's allosteric regulation and oxygen transport mechanisms.

weng cheong
Messages
22
Reaction score
0
where do hydrogen ion(Bohr effect) and 2,3 BPG bind to? porphyrin or just the globin chains?
 
Biology news on Phys.org
The protein chains. BPG binds to deoxy-Hb so favours deoxygenation. A bit unusual in that it binds just one molecule BPG per Hb tetramer (in the cavity between the beta chains).

I believe the Bohr protons bind in lots of places but I am not up to date.

This site is not for getting basic textbook information, more for conceptual difficulties and puzzles when you read the books or try to answer the problems. There is lots on the web e.g. http://www.biochem.arizona.edu/classes/bioc460/spring/460web/lectures/LEC8-9_MbHb_08-ppt.pdf

and lots of others.
 
Last edited by a moderator:

Similar threads

Biology Understanding Allosteric & Competitive Enzyme Inhibitors
  • · Replies 14 ·
Replies
14
Views
3K
Medical Are there theories of medicine that are under the umbrella of Physical Sciences?
  • · Replies 6 ·
Replies
6
Views
3K
Medical Hydrogen water, any good?
  • · Replies 13 ·
Replies
13
Views
6K
Australian Funnel-web spiders and delta-hexatoxin (aka Versutoxin)
  • · Replies 10 ·
Replies
10
Views
2K
COVID Designer viruses as vaccines: yea or nay?
  • · Replies 61 ·
3
Replies
61
Views
5K
Medical Does the net charge of sodium and chloride ions cancel out in salt consumption?
  • · Replies 6 ·
Replies
6
Views
2K
Medical Electrical stimulation of the Vagus nerve may relieve treatment-resistant depression
  • · Replies 1 ·
Replies
1
Views
3K
Medical FDA antidepressant warnings of suicide risk among kids may have the opposite effect
  • · Replies 1 ·
Replies
1
Views
3K
Medical Do statins permanently reduce LDL levels in blood?
  • · Replies 3 ·
Replies
3
Views
2K
Undergrad Is the magnetic moment of a hydrogen atom not equal to Bohr's magneton?
  • · Replies 22 ·
Replies
22
Views
3K