Alternatives to Diethyl Ether to remove pyridine in salt

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SUMMARY

The discussion focuses on alternatives to Diethyl Ether for isolating an organic weak acid from a pyridine salt. The standard method involves dissolving the salt in Diethyl Ether with HCl, followed by evaporation to yield 99% pure organic acid crystals. Participants suggest using less flammable solvents such as dichloromethane, which is highly soluble for the acid, or considering alcohols, which offer mild solubility. The goal is to maintain purity while enhancing safety during the isolation process.

PREREQUISITES
  • Understanding of organic chemistry principles, specifically acid-base reactions.
  • Familiarity with solvent properties, particularly volatility and flammability.
  • Knowledge of purification techniques such as crystallization and evaporation.
  • Experience with handling pyridine and its derivatives safely.
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  • Research the properties and applications of dichloromethane in organic synthesis.
  • Explore alternative solvents for organic acid extraction, focusing on safety and efficiency.
  • Learn about crystallization techniques to enhance the purity of organic compounds.
  • Investigate the use of alcohols in acid-base extraction processes.
USEFUL FOR

Chemists, organic synthesis researchers, and laboratory technicians involved in the purification of organic compounds, particularly those working with pyridine derivatives and seeking safer extraction methods.

barnabe
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Hi,

I make a pyridine salt which contains the pyridine and an organic weak acid. The standard procedure to isolate the acid and remove the pyridine is to dissolve the salt in Diethyl ether with HCL, and let the diethy ether evaporate, which leaves the organic acid crystals with purity 99%.

But i would like to use something else, less flammable than ether to isolate the said acid.
Do you have any idea what could be used?
The acid is composed of C H O and is completely insolube in water. It is mildy soluble in alcohols and quite soluble in dichloromethane.

Thanks for any motivated suggestion.

Regards
 
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I codistill pyridine and heptane to remove the last traces but I usually extract pyridine into acidified water first. Only a little less flammable but much less volatile.
 
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