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"anti-heart attack" shot -- study

  1. Aug 28, 2017 #1

    jim mcnamara

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    http://www.nejm.org/doi/full/10.1056/NEJMoa1707914#t=article
    Canakinumab, a human monoclonal antibody targeting interleukin-1β, has anti-inflammatory effects. These effects were used to establish a new venue for interventions against second heart attacks ( cardiovascular events): controlling the inflammatory response to prevent them.

    The four year study saw a 15% reduction in cardiovascular events in a patient test population of ~10000 persons worldwide who had already had a heart attack, and who had elevated CRP levels. C-reactive protein (CRP) is a precursor in the bio pathway to interleukin-1β.

    A noted side effect was increased rates of infection, since inflammation is also involved in the control of infections.

    See:
    http://www.sciencemag.org/news/2017/08/anti-inflammatory-cuts-risk-heart-attack
    For a more popular science
     
  2. jcsd
  3. Aug 28, 2017 #2

    berkeman

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    Tough tradeoff...
     
  4. Aug 28, 2017 #3
    Interesting! My father in law had trouble breathing a few months ago and they kept him in the hospital because they found elevated CRP levels.
     
  5. Aug 29, 2017 #4

    berkeman

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    Did he have elevated Troponin levels as well? Just curious.

    https://www.ncbi.nlm.nih.gov/pubmed/12651034
     
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