The "span" of a set of vectors in a space is somewhat related to the meaning of this word in English. In a non-mathematics context, we can talk about a bridge that spans (or goes across) a river. In the mathematical context, you might say we can say that a certain set of vectors "goes across" a space, in the sense that I can use the vectors in the set to get to a specific vector. How I use the vectors is to form a linear combination of them, which is the sum of scalar multiples of the vectors.
For example, consider this set of vectors in R3: {(1, 0, 0), (0, 1, 0)}. Do the vectors in this set span R3? There are lots of vectors in R3 that can be written as a linear combination of these vectors. One that can be written this way is (2, 1, 0) = 2(1, 0, 1) + 1(0, 1, 0). On the other hand there are also lots of vectors in R3 that are not linear combinations of the two vectors - there is no linear combination of (1, 0, 0) and (0, 1, 0) that produces (2, 1, 5). For this reason, the vectors (1, 0, 0) and (0, 1, 0) do not span R3.
Although the vectors of my example, (1, 0, 0) and (0, 1, 0), do not span R3, they do span a two-dimensional subspace of R3, the x-y plane.