Can glycerol do this in the body?

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SUMMARY

The discussion centers on the potential link between vaping vegetable glycerin and lipid pneumonia. Participants clarify that glycerol, while hygroscopic, does not draw lipids into the lungs but rather draws water across cell membranes. The chemistry of glycerin, propylene glycol, and their interactions with lipids and water are examined, emphasizing that inhaling vaporized glycerin may not be advisable. The MSDS from Sigma Aldrich for glycerin indicates no data on respiratory exposure, highlighting the need for further research on the effects of inhaling heated glycerin.

PREREQUISITES
  • Understanding of glycerol and its chemical properties
  • Knowledge of lipid chemistry and the differences between lipids and alcohols
  • Familiarity with the concept of hygroscopy
  • Basic awareness of Material Safety Data Sheets (MSDS) and their significance
NEXT STEPS
  • Research the effects of inhaling glycerin and its potential health implications
  • Investigate the role of propylene glycol as a lipid solvent in vaping products
  • Study the chemical interactions between alcohols and lipids in biological systems
  • Explore existing literature on lipid pneumonia and its causes related to vaping
USEFUL FOR

Healthcare professionals, researchers in respiratory health, and individuals concerned about the effects of vaping on lung health will benefit from this discussion.

mjk
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I'm trying to understand lipid pneumonia.

It's been reported that vaping on electronic cigarettes, which contains vegetable glycerine, is the cause of lipid pneumonia. That claim is denied for the reason that vegetable glycerine is not a lipid. It's an alcohol.

But glycerol / vegetable glycerine is also hygroscopic. Does that mean that glycerol can draw the body's fat into the lungs, resulting in lipid pneumonia?

I'm just putting these pieces together and I'd like to see if they make sense to others.

Here are two articles on this topic

http://ucanquit2.org/Vapor

http://www.ecigarette-research.com/web/index.php/2013-04-07-09-50-07/2014/157-glycerol

Thanks for reading and I look forward to replies :)
 
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Hygroscopic materials draw water from the air, not lipids from across cell membranes. Broadly speaking, the chemistry of lipids and water are very different. Lipids are generally non-polar and organic; water is polar and inorganic. So it is improbable that glycerin should react with both water and lipids (although some molecules, such as ethanol and acetone, can solvate both lipids and water). However, glycerin definitely draws water across cell membranes, as this is its basis for a rectal suppository for constipation. So I imagine it is not great to breath in vaporized glycerin. That said, it's also relevant the MSDS from Sigma Aldrich for glycerin lists no data available for respiratory exposure.

It's worth noting propylene glycol, another molecule mentioned in the second article you linked to, is definitely a lipid solvent.
 
RSquared said:
Hygroscopic materials draw water from the air, not lipids from across cell membranes. Broadly speaking, the chemistry of lipids and water are very different. Lipids are generally non-polar and organic; water is polar and inorganic. So it is improbable that glycerin should react with both water and lipids (although some molecules, such as ethanol and acetone, can solvate both lipids and water). However, glycerin definitely draws water across cell membranes, as this is its basis for a rectal suppository for constipation. So I imagine it is not great to breath in vaporized glycerin. That said, it's also relevant the MSDS from Sigma Aldrich for glycerin lists no data available for respiratory exposure.

It's worth noting propylene glycol, another molecule mentioned in the second article you linked to, is definitely a lipid solvent.
Hi RSquared,

I wonder if inhaling heated vegetable glycerine is too new of a phenomenon for such data to be available to the MSDS. Thank you for that link.

If glycerin draws water across cell membranes it makes sense to me that inhaled glycerin could trap water in the lungs (water, not fat, like I previously questioned). Good mention on the ethanol - ethanol is used as a sweetener in e-liquids.

If propylene glycol is a lipid solvent (in addition to ethanol), I'm wondering if vaping provokes a catabolic endogenous response resulting in lipid pneumonia. Because the inhalants are alcohols and not lipids it can't be considered exogenous lipid pneumonia (such as, inhaling kerosene). But I might be completely misunderstanding those terms and functions.

It seems to me that vaping can cause lipid pneumonia but it is very tricky to understand how.

Thanks for the response. :)