Nugatory said:
The paper says no such thing, and we've reached a point in the discussion where pointing to that Nature.com article is no substitute for reading and understanding the paper itself. The paper says that any correspondence between an underlying physical state and the wave functions of pure states must be one-to-one. That's a reasonable basis for claiming that the wave function is ontic, but it doesn't take you to "physically real".
This is not even true for minimally interpreted quantum theory (and that's the only interpretation that does not lead to contradictions with basic principles like causality): A pure state is represented by a ray in Hilbert space.
I still don't understand don't understand what "real" means in this thread, but if anything is "real" concerning quantum states, it's rays in Hilbert space. I would define an object in a physical theory "real" if it can be measured somehow in the real world. In this sense the quantum states are not real, because their physical content is probabilistic and thus can be checked in the lab only by preparing many independent realizations of the corresponding system and measure some observables on them. At the same time the quantum states are objective, because interpreted in this way they are operationally defined by (an equivalence class of) preparation procedures, e.g., how to prepare electrons with a certain momentum within given limits of accuracy (an electron never can have a sharp momentum as in classical physics however, due to the uncertainty relation, but in principle it can be determined with any accuracy you like). The "preparation procedure" is, e.g., an accelerator with all kinds of tricks to get electrons with a "well-defined" momentum. These are for sure real objects in the real worlds, and in this sense the states are "real" in the sense of preparation procedures.
I've the impression PBR's ontology is demanding more than quantum theory in the minimal interpretation, namely that all observables of a quantum object should "in reality" have determined values. That means they take the state description as "real" only if it determines all possible observables, but this contradicts quantum theory, and so far nobody has found an alternative theory which is as successful. Also it seems to me that PBR don't give any description of how the alternatives of an ontic vs. an epistemic interpretation of QT states can be distinguished experimentally in the "real world". That makes their ideas a bit limited in the sense of natural science.
An example of this kind is Bell's work. First of all he gives a clear mathematical description to the "reality" in the sense of EPR and then proves a theorem (the famous "Bell inequality") that can be tested in the "real world" by doing experiments, and this has been done with high accuracy (starting with Aspect's work in the 80ies). The outcome is very clear: If there is a deterministic theory reproducing the quantum probabilities it must be a non-local one, and so far nobody has been able to formulate such a theory. At the same time the predictions of QT have been confirmed.