Can the Nernst Equation Determine Missing Sodium Concentrations?

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SUMMARY

The discussion centers on using the Nernst Equation to calculate missing sodium (Na+) concentrations in extracellular fluid (ECF) and intracellular fluid (ICF) based on provided ion concentrations. The Nernst Equation, expressed as Em = 58/z * log(xo/xi), is applicable for determining equilibrium potentials for ions. Participants suggest calculating the equilibrium potential for chloride (Cl-) first, followed by potassium (K+), to establish a framework for deducing Na+ concentrations. The conversation emphasizes the importance of charge neutrality in the calculations.

PREREQUISITES
  • Understanding of the Nernst Equation and its application in electrochemistry
  • Knowledge of ion concentrations in biological systems
  • Familiarity with concepts of equilibrium potential and charge neutrality
  • Basic principles of ion transport mechanisms, particularly symporters
NEXT STEPS
  • Study the Nernst Equation in detail, including its derivation and applications
  • Research the role of symporters in ion transport and their impact on cellular ion concentrations
  • Explore methods for measuring ion concentrations in biological samples
  • Investigate the concept of net neutrality in biological systems and its implications for ion balance
USEFUL FOR

This discussion is beneficial for neurophysiologists, biochemists, and anyone involved in cellular physiology or ion transport research, particularly those interested in calculating ion concentrations using electrochemical principles.

tqsld
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A rather tame ltxnsp was recently found on Easter Island by a retired neurophysiologist. He reported the following measurements of ECF and ICF concentrations (in millimoles):
ICF ECF
Pr+ 0 150
Na+ ? ?
K+ 10 100
Cl- 109 250
HCO3- 1 10


so this is the question: He lacked the proper instruments for determining Na+ concentrations, but was rather certain that no other major ions were present in the ECF and ICF. Can you calculate either concentration for him?

I think we use the Nernst eqn in this case to figure it out which is Em= 58/ z * log (xo/xi). correct me if I'm wrong. So Na and Cl is transported via the symporter so only charges are opposite. therefore we find the Em of Cl-? Then after that we find what's K? But then I don't get how to use those to tie it to find Na. I'm confusing myself here. Can someone help me out.
 
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Try using net neutrality of the bulk.
 

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