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Medical Chronic back pain causes brain shrinkage

  1. Aug 2, 2006 #1
    Last edited by a moderator: Apr 22, 2017
  2. jcsd
  3. Aug 3, 2006 #2


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    I didn't catch a mechanism of why that might happen.
  4. Aug 3, 2006 #3
    Here is one hypothesis that was stated:
    “Given that, by definition, chronic pain is a state of continuous persistent perception with associated negative affect and stress, one mechanistic explanation for the decreased gray matter is overuse atrophy caused by excitotoxic and inflammatory mechanisms,” Apkarian said."
  5. Aug 3, 2006 #4


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    I have no idea what that red part means. He's saying parts of the guys' brains were overused?
  6. Aug 4, 2006 #5
    http://en.wikipedia.org/wiki/Cerebral_atrophy" [Broken]
    http://www.biochem.northwestern.edu/holmgren/Glossary/Definitions/Def-E/excitotoxins.html" [Broken]

    Parts of the brain were chronically stimulated by the pain. This caused the production of the excitotoxins -----> inflammatory response-----> loss of brain cells.
    Last edited by a moderator: May 2, 2017
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