I understand that a cyclohexane is usually more stable when the substituted group, like methyl, is in the equatorial axis. However, is it possble to determine the stability between, say, trans-1,2-dimethylcyclohexane and cis-1,3-dimethylcyclohexane. My guess is that the trans-1,2-dimethyl is least stable because the methyl groups are closer together? how about trans-1,4-dimethylcyclohexane and cis-1,4-dimethylcyclohexane? they are both on opposite sides, so how can you tell?