Ckg733 the so-called anti-aging molecule - how to control aging?

[bioquest]

ckg733 the so-called "anti-aging molecule" - how to control aging?

I've heard ckg733 be called the "anti-aging molecule" and apparently it can reverse aging of cells? Could this be used to reverse/stop the aging of an organism? I mean if you can control the age etc of every cell you could use it to stop/reverse the aging of an organism right?

 

[jim mcnamara]

Short answer: probably not. Currently it is being looked at in the area of wound healing.

From what I've read, it does not sound like a panacea for ageing. In laymen's terms: it apparently stops the cells from marking the cell as "old", and in need of replacement (usually due to DNA damage). Instead the cell keeps on going, like the Energizer Bunny.
Which is good in wound healing. But. DNA damage is directly related to the probability of the start of cancer. Which is bad for the organism's longterm survival.

by the way it is: CGK733 and it is a manmade chemical

 

[bioquest]

Can CGK733 only extend the lifespan of a cell by about 25%/approx 20 divisions?

 

[jim mcnamara]

I do not know how much "life" extension cells have in those experiments. Mainly because a pubmed search doesn't show me any refereed journal entries, just blurbs in newspapers, science websites citing the blurbs and some health/life extension websites.

My take is that if there has been no more research published since early 2006, then maybe the hype is just that - hype with little substance.

If you are interested in semi-immortailty, consider going on a lifelong restricted calorie diet. These are known to extend mouse lifespans by 20% - 40%.
Human trials are underway according to:
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1196473

 

[bioquest]

I'm interested in life extension that is more than 50% or 100%
I don't think huge life extension/near immortality is at all impossible I just don't think that we're anywhere near it right now. Maybe we'll come closer with discoveries in nanotechnology and things like that. So I'm interested in things relating to life extension...I kind of just wanted to know the maximum amount cgk733 could hypothetically extend human life right now, if it weren't for cancer etc and then I wanted to update myself on progress with it in future

 

[bioquest]

I did read stuff about human trials with CGK733
Basically I just wanted to know if it could only extend the lifetime of cultured cells by approximately 20 divisions or it could extend them more than that (mentioned here) http://en.wikipedia.org/wiki/Cgk733

 

[jim mcnamara]

Oh, I see what you mean. 20 divisions could be a substantial time by the way.
I still can't see a copy of Tae Kook Kim's abstract.

Just a lot of stuff at the Immortality Institute, for example.

Anyway, according to Wikipedia (note: you should read original research if possible because Wikipedia is only moderately reliable on some things), yes, it does extend the "lifepsan" of cells more than than 20 divisions. So, if you accept this, it could creeate a cell culture line that could live for years.

If you google for 'cgk733' virtually every hit you get is a secondary or tertiary reference.
If you see lots of sites that promote something or are 'science news sites' it means there is a lot more going on outside, rather than inside, science. Basically it means you can't believe everything you read on the internet.

Until I can read at least a paper or two on this, I simply cannot tell you anything reliably. If that doesn't bother you, just read Wikipedia. It has lots of stuff.

 

[bioquest]

But what I wanted to know was how many divisions (probably) at CGK733's maximum potential could it currently, at the moment, increase a cell's ability to do I am not asking for super reliable information just best guesses and the reasons for them

would 20 divisions= 25% more life extension of cell?

 

[NoTime]

I think the Hayflick limit is considered to be about 50 cell divisions.
This may vary somewhat with cell type.
So an increase of 20 divisions is not quite a 25% increase.

 

[bioquest]

okay but could CGK733 now, currently, cause cells to divide any amount of times? 50 times, 100 times more than it would? What's the highest number CGK733 could hypothetically have cells divide more than they would otherwise currently?
(Approx. Why or why not. in your opinions) or can it currently pretty much only cause a cell to divide 20 times more than it otherwise would?
thanks

 

[NoTime]

Having an opinion without some more concrete data isn't particularly useful.
From the little I can find, it seems to work by bypassing a DNA repair checkpoint.
This implies that the cells would be more inclined to become cancerous or if enough damage accumulated activate some other senescence mechanisim.
It doesn't speak well to larger increases in division count.

Interesting find.
We will have to see what is discovered with further research.

 

[jim mcnamara]

Notime -

I made exactly those points about degnerate DNA in another thread. The OP wants somebody to speculate, I guess. There is no science basis I can find to even speculate against. Just "news" which is not science.

I give up.

 

[bioquest]

I reread your pm where you said

"You do understand that cancer is basically cells that spend all of their time dividing and making more cells, rather than differentiating and becoming something more constructive for an organism?"

I was just trying to find scientific info on CGK733..it kind of sucks that there isn't very much though so oh well

 

[jim mcnamara]

I am very old relative most folks here on PF.

I've seen a lot of discoveries that went flop. The lack of more papers usually indicates some kind of problem. Unless the guy works for the manufacturing firm (or some "institute", like the sugar institute reporting ) then you'll see a bunch more papers because it's in somebody's financial interest to publish more.

Not all scienctific publications are equal.