Deceptive curcumin offers cautionary tale for chemists

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SUMMARY

The discussion centers on the cautionary tale regarding curcumin, as highlighted in the article from Nature. It emphasizes that chemists have long warned about the misleading nature of curcumin and similar compounds for drug discovery. The conversation raises broader questions about the chemical properties of natural products and their therapeutic potential, suggesting that many may possess undesirable characteristics yet still hold significant clinical value.

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  • Familiarity with drug discovery processes
  • Knowledge of therapeutic applications of chemical compounds
  • Awareness of the limitations of chemical structure in medicinal chemistry
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  • Research the chemical properties of curcumin and its analogs
  • Explore the role of natural products in modern pharmacology
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Chemists, pharmacologists, and researchers interested in natural products and their applications in drug development will benefit from this discussion.

lavoisier
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FYI

http://www.nature.com/news/deceptive-curcumin-offers-cautionary-tale-for-chemists-1.21269

Funny they should say the 'cautionary tale' is 'for chemists', given that the article itself then says:
'For years, chemists have urged caution about curcumin and other compounds that can mislead naive drug hunters.'

More in general, I wonder how many natural products are chemically just as ugly as curcumin, but nevertheless do have important applications in therapy.
 
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lavoisier said:
More in general, I wonder how many natural products are chemically just as ugly as curcumin, but nevertheless do have important applications in therapy.
How many "natural products" are there at least as ugly as curcumin?
 
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